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Activation of Cdc42 leads to the formation of a PAK1/TRAF6/TAK1 complex, the phosphorylation of PAK1 at Ser223, and the subsequent activation of NF-κB and production of pro-inflammatory cytokines. The ensuing intestinal inflammation allows Salmonella to out-compete the resident microbiota and replicate within the lumen of the intestinal tract. At the same time, the inflammatory response controls the spread of Salmonella to deeper tissues. https://images.squarespace-cdn.com/content/v1/56f431d11d07c0ae202126d3/1458848075221-HIUZORVN9XG2CN7B2LJP/Fig.+3.jpg Overview Fig. 3. 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