Selected recent publications:

2019

Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system. Maria Lara-Tejero, Zhuan Qin, Bo Hu, Carmen Butan, Jun Liu, Jorge E. Galán. PLoS Pathog. 2019 Jan 22;15(1):e1007565. doi: 10.1371/journal.ppat.1007565.

2018

Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin. Tobias Geiger, Manuel Pazos, Maria Lara-Tejero, Waldemar Vollmer, Jorge E. Galán. Nat Microbiol. 2018 Nov;3(11):1243-1254. doi: 10.1038/s41564-018-0248-x.

Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors. Hui Sun, Jana Kamanova , Maria Lara-Tejero, Jorge E. Galán. Nat Microbiol. 2018 Oct;3(10):1122-1130. doi: 10.1038/s41564-018-0246-z.

A protein secreted by the Salmonella type III secretion system controls needle filament assembly. Junya Kato, Supratim Dey, Jose E Soto, Carmen Butan, Mason C Wilkinson, Roberto N De Guzman, Jorge E Galán. Elife. 2018 Jul 17;7. pii: e35886. doi: 10.7554/eLife.35886.

Protein-Injection Machines in Bacteria. Jorge E. Galán, Gabriel Waksman. Cell. 2018 Mar 8;172(6):1306-1318. doi: 10.1016/j.cell.2018.01.034.

Decoding a Salmonella Typhi Regulatory Network that Controls Typhoid Toxin Expression within Human Cells. Casey C. Fowler, Jorge E. Galán. Cell Host Microbe. 2018 Jan 10;23(1):65-76.e6. doi: 10.1016/j.chom.2017.12.001.

2017

Evolution of host adaptation in the Salmonella typhoid toxin. Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki, Jorge E. Galán. Nat Microbiol. 2017 Dec;2(12):1592-1599. doi: 10.1038/s41564-017-0033-2.

Salmonella enterica serovar-specific transcriptional reprogramming of infected cells. Sebastian Hannemann, Jorge E. Galán. PLoS Pathog. 2017 Jul 24;13(7):e1006532. doi: 10.1371/journal.ppat.1006532.

2016

Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi. Galán JE. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6338-44. doi: 10.1073/pnas.1606335113.

The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members. Kamanova J, Sun H, Lara-Tejero M, Galán JE. PLoS Pathog. 2016 Apr 8;12(4):e1005552. doi: 10.1371/journal.ppat.1005552.

A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis. Sun H, Kamanova J, Lara-Tejero M, Galán JE. PLoS Pathog. 2016 Mar 2;12(3):e1005484. doi: 10.1371/journal.ppat.1005484.

Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F. Cell. 2016 Feb 25;164(5):827-8. doi: 10.1016/j.cell.2016.02.015.

Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach. Zilkenat S, Franz-Wachtel M, Stierhof YD, Galán JE, Macek B, Wagner S. Mol Cell Proteomics. 2016 May;15(5):1598-609. doi: 10.1074/mcp.M115.056598.

A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP. Spanò S, Gao X, Hannemann S, Lara-Tejero M, Galán JE. Cell Host Microbe. 2016 Feb 10;19(2):216-26. doi: 10.1016/j.chom.2016.01.004.

Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC. J Am Chem Soc. 2016 Feb 24;138(7):2209-18. doi: 10.1021/jacs.5b11575.

2015

Role of autocleavage in the function of a type III secretion specificity switch protein in Salmonella enterica serovar Typhimurium. Monjarás Feria JV, Lefebre MD, Stierhof YD, Galán JE, Wagner S. MBio. 2015 Oct 13;6(5):e01459-15. doi: 10.1128/mBio.01459-15.

Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase. Kato J, Lefebre M, Galán JE. J Bacteriol. 2015 Sep;197(18):3007-14. doi: 10.1128/JB.00434-15.

2014

Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057.

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Galán JE, Lara-Tejero M, Marlovits TC, Wagner S. Annu Rev Microbiol. 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725.

Novel components of the flagellar system in epsilonproteobacteria. Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE. MBio. 2014 Jun 24;5(3):e01349-14. doi: 10.1128/mBio.01349-14.

NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN. J Mol Biol. 2014 Aug 12;426(16):2958-69. doi: 10.1016/j.jmb.2014.06.009.

Structural and enzymatic characterization of a host-specificity determinant from Salmonella. Kohler AC, Spanò S, Galán JE, Stebbins CE. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):384-91. doi: 10.1107/S1399004713028393.

The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Lefebre MD, Galán JE. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):817-22. doi: 10.1073/pnas.1319698111.

2013

A novel anti-microbial function for a familiar Rab GTPase. Spanò S, Galán JE. Small GTPases. 2013 Oct-Dec;4(4):252-4. doi: 10.4161/sgtp.27282.

Salmonella modulation of host cell gene expression promotes its intracellular growth. Hannemann S, Gao B, Galán JE. PLoS Pathog. 2013;9(10):e1003668. doi: 10.1371/journal.ppat.1003668.

Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Song J, Gao X, Galán JE. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377.

Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Hicks SW, Galán JE. Nat Rev Microbiol. 2013 May;11(5):316-26. doi: 10.1038/nrmicro3009. Review.

An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA. Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. Cell. 2013 Mar 28;153(1):166-77. doi: 10.1016/j.cell.2013.02.037.

Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Carleton HA, Lara-Tejero M, Liu X, Galán JE. Nat Commun. 2013;4:1590. doi: 10.1038/ncomms2594.

2012

Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model. Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE. PLoS One. 2012;7(11):e50699. doi: 10.1371/journal.pone.0050699.

A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion. Hodak H, Galán JE. EMBO Rep. 2013 Jan;14(1):95-102. doi: 10.1038/embor.2012.186.

A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Spanò S, Galán JE. Science. 2012 Nov 16;338(6109):960-3. doi: 10.1126/science.1229224.

The Salmonella type III secretion system inner rod protein PrgJ is partially folded. Zhong D, Lefebre M, Kaur K, McDowell MA, Gdowski C, Jo S, Wang Y, Benedict SH, Lea SM, Galan JE, De Guzman RN. J Biol Chem. 2012 Jul 20;287(30):25303-11. doi: 10.1074/jbc.M112.381574.

Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. Liu X, Gao B, Novik V, Galán JE. PLoS Pathog. 2012;8(3):e1002562. doi: 10.1371/journal.ppat.1002562.