Selected recent publications:

2016

Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi. Galán JE. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6338-44. doi: 10.1073/pnas.1606335113. Epub 2016 May 24.

The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members. Kamanova J, Sun H, Lara-Tejero M, Galán JE. PLoS Pathog. 2016 Apr 8;12(4):e1005552. doi: 10.1371/journal.ppat.1005552. eCollection 2016 Apr.

A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis. Sun H, Kamanova J, Lara-Tejero M, Galán JE. PLoS Pathog. 2016 Mar 2;12(3):e1005484. doi: 10.1371/journal.ppat.1005484. eCollection 2016 Mar.

Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F. Cell. 2016 Feb 25;164(5):827-8. doi: 10.1016/j.cell.2016.02.015. No abstract available.

Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach. Zilkenat S, Franz-Wachtel M, Stierhof YD, Galán JE, Macek B, Wagner S. Mol Cell Proteomics. 2016 May;15(5):1598-609. doi: 10.1074/mcp.M115.056598. Epub 2016 Feb 21.

A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP. Spanò S, Gao X, Hannemann S, Lara-Tejero M, Galán JE. Cell Host Microbe. 2016 Feb 10;19(2):216-26. doi: 10.1016/j.chom.2016.01.004.

Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC. J Am Chem Soc. 2016 Feb 24;138(7):2209-18. doi: 10.1021/jacs.5b11575. Epub 2016 Feb 16.

2015

Role of autocleavage in the function of a type III secretion specificity switch protein in Salmonella enterica serovar Typhimurium. Monjarás Feria JV, Lefebre MD, Stierhof YD, Galán JE, Wagner S. MBio. 2015 Oct 13;6(5):e01459-15. doi: 10.1128/mBio.01459-15.

Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase. Kato J, Lefebre M, Galán JE. J Bacteriol. 2015 Sep;197(18):3007-14. doi: 10.1128/JB.00434-15. Epub 2015 Jul 13.

2014

Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057.

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Galán JE, Lara-Tejero M, Marlovits TC, Wagner S. Annu Rev Microbiol. 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725. Epub 2014 Jun 18. Review.

Novel components of the flagellar system in epsilonproteobacteria. Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE. MBio. 2014 Jun 24;5(3):e01349-14. doi: 10.1128/mBio.01349-14.

NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN. J Mol Biol. 2014 Aug 12;426(16):2958-69. doi: 10.1016/j.jmb.2014.06.009. Epub 2014 Jun 18.

Structural and enzymatic characterization of a host-specificity determinant from Salmonella. Kohler AC, Spanò S, Galán JE, Stebbins CE. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):384-91. doi: 10.1107/S1399004713028393. Epub 2014 Jan 29.

The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Lefebre MD, Galán JE. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):817-22. doi: 10.1073/pnas.1319698111. Epub 2013 Dec 30.

2013

A novel anti-microbial function for a familiar Rab GTPase. Spanò S, Galán JE. Small GTPases. 2013 Oct-Dec;4(4):252-4. doi: 10.4161/sgtp.27282. Epub 2013 Dec 9. Review.

Salmonella modulation of host cell gene expression promotes its intracellular growth. Hannemann S, Gao B, Galán JE. PLoS Pathog. 2013;9(10):e1003668. doi: 10.1371/journal.ppat.1003668. Epub 2013 Oct 3.

Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Song J, Gao X, Galán JE. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10.

Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Hicks SW, Galán JE. Nat Rev Microbiol. 2013 May;11(5):316-26. doi: 10.1038/nrmicro3009. Review.

An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA. Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. Cell. 2013 Mar 28;153(1):166-77. doi: 10.1016/j.cell.2013.02.037.

Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Carleton HA, Lara-Tejero M, Liu X, Galán JE. Nat Commun. 2013;4:1590. doi: 10.1038/ncomms2594.

2012

Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model. Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE. PLoS One. 2012;7(11):e50699. doi: 10.1371/journal.pone.0050699. Epub 2012 Nov 30.

A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion. Hodak H, Galán JE. EMBO Rep. 2013 Jan;14(1):95-102. doi: 10.1038/embor.2012.186. Epub 2012 Nov 23.

A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Spanò S, Galán JE. Science. 2012 Nov 16;338(6109):960-3. doi: 10.1126/science.1229224.

The Salmonella type III secretion system inner rod protein PrgJ is partially folded. Zhong D, Lefebre M, Kaur K, McDowell MA, Gdowski C, Jo S, Wang Y, Benedict SH, Lea SM, Galan JE, De Guzman RN. J Biol Chem. 2012 Jul 20;287(30):25303-11. doi: 10.1074/jbc.M112.381574. Epub 2012 May 31.

Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. Liu X, Gao B, Novik V, Galán JE. PLoS Pathog. 2012;8(3):e1002562. doi: 10.1371/journal.ppat.1002562. Epub 2012 Mar 8.